Intracoronary Infusion of Small Doses of Nifedipine Lowers Regional Myocardial O2-consumption Without Altering Regional Myocardial Function

Overview

Journal Basic Res Cardiol

Specialty Cardiology & Vascular Diseases

Date 1982 Jan 1

PMID 7073651

Citations 3

Authors

P D Verdouw

F J Ten Cate

J M Hartog

M G Scheffer

H Stam

Affiliations

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Abstract

Intracoronary infusion of low doses (0.1-0.3 microgram X kg-1) of nifedipine caused dose-dependent decreases in regional myocardial O2-consumption, without significant changes in any of its major global hemodynamic determinants: heart rate, left ventricular systolic and end-diastolic pressure and maxLVdP/dt. Furthermore, regional myocardial function was unaltered. It is suggested that nifedipine decreased myocardial O2-consumption by a direct effect on myocardial metabolism. Some of the possible mechanisms involved are discussed.

Citing Articles

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Effect of nifedipine on the myocardial and vascular response to myocardial ischemia.

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Coronary thrombolysis with and without nifedipine in pigs.

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