Inhibition of Postprandial Pancreatic and Biliary Secretion by Loperamide in Patients with Short Bowel Syndrome

Overview

Journal Gut

Specialty Gastroenterology

Date 1982 Feb 1

PMID 7068042

Citations 8

Authors

M REMINGTON

C R Fleming

J R Malagelada

Affiliations

Soon will be listed here.

Abstract

Patients with the short bowel syndrome are usually afflicted by chronic diarrhoea and treated with opiate drugs, yet little documentation of the effects of such drugs on digestive function is available. In the present study we found that acute oral administration of loperamide resulted in 50% inhibition of postprandial trypsin and bilirubin output in patients with short bowel syndrome. These changes are consistent with an opiate effect.

Citing Articles

How to manage a high-output stoma.

Nightingale J Frontline Gastroenterol. 2022; 13(2):140-151.

PMID: 35300464 PMC: 8862462. DOI: 10.1136/flgastro-2018-101108.

Sphincter of Oddi Function and Risk Factors for Dysfunction.

Afghani E, Lo S, Covington P, Cash B, Pandol S Front Nutr. 2017; 4:1.

PMID: 28194398 PMC: 5276812. DOI: 10.3389/fnut.2017.00001.

Intestinal Failure: New Definition and Clinical Implications.

Kappus M, Diamond S, Hurt R, Martindale R Curr Gastroenterol Rep. 2016; 18(9):48.

PMID: 27447791 DOI: 10.1007/s11894-016-0525-x.

The pharmacologic treatment of short bowel syndrome: new tricks and novel agents.

Bechtold M, McClave S, Palmer L, Nguyen D, Urben L, Martindale R Curr Gastroenterol Rep. 2014; 16(7):392.

PMID: 25052938 DOI: 10.1007/s11894-014-0392-2.

Enteral drug absorption in patients with short small bowel : a review.

Severijnen R, Bayat N, Bakker H, Tolboom J, Bongaerts G Clin Pharmacokinet. 2004; 43(14):951-62.

PMID: 15530127 DOI: 10.2165/00003088-200443140-00001.

References

Barbezat G, Hansen J . The exocrine pancreas and protein-calorie malnutrition. Pediatrics. 1968; 42(1):77-92. View

Go V, Hofmann A, Summerskill W . Simultaneous measurements of total pancreatic, biliary, and gastric outputs in man using a perfusion technique. Gastroenterology. 1970; 58(3):321-8. View

Johansson C, LAGERLOF H, Ekelund K, Kulsdom N, Larsson I, Nylind B . Studies of gastrointestinal interactions. 3. Determination of gastric secretion and evacuation, biliary and pancreactic secretion, intestinal absorption, intestinal transit time and flow of water in man. Scand J Gastroenterol. 1972; 7(5):489-99. DOI: 10.3109/00365527209180775. View

DiMagno E, Go V, Summerskill W . Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. N Engl J Med. 1973; 288(16):813-5. DOI: 10.1056/NEJM197304192881603. View

MEEROFF J, Go V, Phillips S . Gastric emptying of liquids in man. Quantification by duodenal recovery marker. Mayo Clin Proc. 1973; 48(10):728-32. View

Hofmann A, Danzinger R . Physiologic and clinical significance of ileal resection. Surg Annu. 1972; 4:305-25. View

NIEMEGEERS C, Lenaerts F, Janssen P . Loperamide (R 18 553), a novel type of antidiarrheal agent. Part 1: in vivo oral pharmacology and acute toxicity. Comparison with morphine, codeine, diphenoxylate and difenoxine. Arzneimittelforschung. 1974; 24(10):1633-6. View

GALAMBOS J, Hersh T, Schroder S, Wenger J . Loperamide: a new antidiarrheal agent in the treatment of chronic diarrhea. Gastroenterology. 1976; 70(6):1026-9. View

Sacchetti G, Roncoroni L, MANDELLI V, Rocca F, Magni E . Effect of analgesic agents on emptying of the gallbladder in man. Eur J Clin Pharmacol. 1976; 10(2):127-31. DOI: 10.1007/BF00609471. View

10.

MacGregor I, MARTIN P, Meyer J . Gastric emptying of solid food in normal man and after subtotal gastrectomy and truncal vagotomy with pyloroplasty. Gastroenterology. 1977; 72(2):206-11. View

11.

Tytgat G, Huibregtse K, Dagevos J, van den Ende A . Effect of loperamide on fecal output and composition in well-established ileostomy and ileorectal anastomosis. Am J Dig Dis. 1977; 22(8):669-76. DOI: 10.1007/BF01078345. View

12.

Levitt M, Bond J . Use of the constant perfusion technique in the nonsteady state. Gastroenterology. 1977; 73(6):1450-3. View

13.

Konturek S, TASLER J, Cieszkowski M, Jaworek J, Coy D, Schally A . Inhibition of pancreatic secretion by enkephalin and morphine in dogs. Gastroenterology. 1978; 74(5 Pt 1):851-5. View

14.

Kotler D, Levine G . Reversible gastric and pancreatic hyposecretion after long-term total parenteral nutrition. N Engl J Med. 1979; 300(5):241-2. DOI: 10.1056/NEJM197902013000508. View

15.

Miller L, Clain J, Malagelada J, Go V . Control of human postprandial pancreatic exocrine secretion: a function of the gastroduodenal region. Dig Dis Sci. 1979; 24(2):150-4. DOI: 10.1007/BF01324743. View

16.

Ambinder R, SCHUSTER M . Endorphins: new gut peptides with a familiar face. Gastroenterology. 1979; 77(5):1132-40. View

17.

Roze C, DUBRASQUET M, CHARIOT J, VAILLE C . Central inhibition of basal pancreatic and gastric secretions by beta-endorphin in rats. Gastroenterology. 1980; 79(4):659-64. View

18.

Rowlands E, CHAPMAN W, Taylor A, Jones C . Multiple balloon kymograph recording of the comparative action of morphine and placebos on the motility of the upper small intestine in man. Surg Gynecol Obstet. 1950; 91(2):129-37. View