Ethically Optimised Designs

Overview

Journal Br J Clin Pharmacol

Specialty Pharmacology

Date 1982 Apr 1

PMID 7066161

Citations 4

Authors

D G Clayton

Affiliations

Soon will be listed here.

Citing Articles

Outcome-adaptive randomization in clinical trials: issues of participant welfare and autonomy.

Sim J Theor Med Bioeth. 2019; 40(2):83-101.

PMID: 30778720 PMC: 6478640. DOI: 10.1007/s11017-019-09481-0.

Methodological choices for the clinical development of medical devices.

Bernard A, Vaneau M, Fournel I, Galmiche H, Nony P, Dubernard J Med Devices (Auckl). 2014; 7:325-34.

PMID: 25285025 PMC: 4181748. DOI: 10.2147/MDER.S63869.

Confounding due to changing background risk in adaptively randomized trials.

Lipsky A, Greenland S Clin Trials. 2011; 8(4):390-7.

PMID: 21610005 PMC: 3425438. DOI: 10.1177/1740774511406950.

[Clinical trial under trial. 'Trial and error'].

ROSINGA W Pharm Weekbl Sci. 1983; 5(1):1-8.

PMID: 6341963 DOI: 10.1007/BF01959644.

References

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Simon R . Adaptive treatment assignment methods and clinical trials. Biometrics. 1977; 33(4):743-9. View

Skegg D, DOLL R . The case for recording events in clinical trials. Br Med J. 1977; 2(6101):1523-4. PMC: 1632767. DOI: 10.1136/bmj.2.6101.1523. View

Freiman J, CHALMERS T, SMITH Jr H, Kuebler R . The importance of beta, the type II error and sample size in the design and interpretation of the randomized control trial. Survey of 71 "negative" trials. N Engl J Med. 1978; 299(13):690-4. DOI: 10.1056/NEJM197809282991304. View

Altman D . Statistics and ethics in medical research. Misuse of statistics is unethical. Br Med J. 1980; 281(6249):1182-4. PMC: 1714517. DOI: 10.1136/bmj.281.6249.1182. View