Influence of Fasting on Intestinal Permeability and Disease Activity in Patients with Rheumatoid Arthritis

Overview

Journal Scand J Rheumatol

Publisher Informa Healthcare

Specialty Rheumatology

Date 1982 Jan 1

PMID 7063809

Citations 23

Authors

T Sundqvist

F Lindstrom

K E Magnusson

L Skoldstam

I Stjernstrom

C Tagesson

Affiliations

Soon will be listed here.

Abstract

We have investigated the influence of fasting and lactovegetarian diet on intestinal and non-intestinal permeability in 5 patients with rheumatoid arthritis. We used low-molecular weight polyethyleneglycols (PEG 400) as probe molecules and a deterministic mathematical model to assess the permeability characteristics. Both intestinal and non-intestinal permeability decreased after fasting, but increased again during a subsequent lactovegetarian diet regime. Concomitantly it appeared that disease activity, as shown by a clinical six-joint score, first decreased and then increased again. The results indicate that, unlike lactovegetarian diet, fasting may ameliorate the disease activity and reduce both the intestinal and the non-intestinal permeability in rheumatoid arthritis.

Citing Articles

Effect of Intermittent Fasting on Immune Parameters and Intestinal Inflammation.

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What do we know about dietary perceptions and beliefs of patients with rheumatoid arthritis? A scoping review.

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Re-evaluation of dietary interventions in rheumatoid arthritis: can we improve patient conversations around food choices?.

Sharma P, Brown S, Sokoya E Rheumatol Int. 2024; 44(8):1409-1419.

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Intestinal Microbiota Reduction Followed by Fasting Discloses Microbial Triggering of Inflammation in Rheumatoid Arthritis.

Haupl T, Sorensen T, Smiljanovic B, Darcy M, Scheder-Bieschin J, Steckhan N J Clin Med. 2023; 12(13).

PMID: 37445394 PMC: 10342944. DOI: 10.3390/jcm12134359.