Cells Bearing Fc Receptors in Human Malignant Solid Tumours

Overview

Journal Br J Cancer

Specialty Oncology

Date 1982 Feb 1

PMID 7059470

Citations 5

Authors

J L Svennevig

T R Andersson

Affiliations

Soon will be listed here.

Abstract

Fc-receptor-bearing cells forming EA rosettes with antibody-coated human erythrocytes (Ripley) were studied in cell suspensions and in purified preparations of mononuclear cells (MC) from 20 human malignant tumours. The EA rosettes were studied in preparations made by cytocentrifugation and the rosette-forming cells identified by their nonspecific-esterase activity and phagocytic capacity. Fc receptors were found on 16 +/- 20% of all cells in the primary cell suspensions. Significantly more tumour-infiltrating lymphocytes had detectable Fc receptors normal control subjects (14 +/- 6%). There was a significant correlation between the proportion of lymphocytes lacking T and B markers (null cells) and the proportion of lymphocytes with Fc receptors. Fc receptors were also found on most tumour-infiltrating macrophages, on some T lymphocytes and polymorphonuclear cells and on a smaller percentage of the tumour cells. The significance of the Fc receptor and its usefulness as a marker of "host infiltration" into the tumours is discussed.

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