Alanine Inhibition of Pyruvate Kinase in Gliomas and Meningiomas. A Diagnostic Tool in Surgery for Gliomas?

Overview

Journal Lancet

Publisher Elsevier

Specialty General Medicine

Date 1977 Aug 20

PMID 70592

Citations 9

Authors

C W van Veelen

G E Staal

H VERBIEST

A M Vlug

Affiliations

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Abstract

In gliomas a shift was found in the composition of enzymes, manifested by abnormal inhibition of pyruvate kinase by alanine. This study demonstrates the appearance of the MII-type isoenzyme in various gliomas. This MII type is also found in meningiomas but not in normal brain tissue. The method of enzyme examination described may be valuable as a diagnostic aid in the surgery of gliomas.

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