Divalent Cations and Chlorpromazine Can Induce Non-bilayer Structures in Phosphatidic Acid-containing Model Membranes

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1982 Jan 22

PMID 7055567

Citations 32

Authors

A J Verkleij

R De Maagd

B de Kruijff

Affiliations

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Abstract

(1) The structural organization of aqueous dispersions of 1,2-dioleoylphosphatidic acid has been investigated by freeze-fracture electron microscopy in relation to variations in pH, divalent cations and the local anaesthetic chlorpromazine. (2) In the pH range 4--8 in the presence of 100 mM Na+, dioleoylphosphatidic acid is organized in bilayers. (3) At pH 6 and not at pH 4 and 8.5 addition of Ca2+, Mg2+, Mn2+ and chlorpromazine results in the formation of the hexagonal HII phase. (4) Ca2+ and chlorpromazine addition to mixed phosphatidylcholine-dioleoylphosphatidic acid bilayers at pH 6 results in the formation of lipidic particles.

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