Alpha 2.0
Login Register
» Articles » PMID: 7048259

Use of the 'Perceptron' Algorithm to Distinguish Translational Initiation Sites in E. Coli

Overview
Journal Nucleic Acids Res
Publisher Oxford University Press
Specialty Biochemistry
Date 1982 May 11
PMID 7048259
Citations 264
Authors
G D Stormo
T D Schneider
L Gold
A Ehrenfeucht
Affiliations
Soon will be listed here.
Abstract

We have used a "Perceptron" algorithm to find a weighting function which distinguishes E. coli translational initiation sites from all other sites in a library of over 78,000 nucleotides of mRNA sequence. The "Perceptron" examined sequences as linear representations. The "Perceptron" is more successful at finding gene beginnings than our previous searches using "rules" (see previous paper). We note that the weighting function can find translational initiation sites within sequences that were not included in the training set.

Citing Articles

Experimental approaches to investigate biophysical interactions between homeodomain transcription factors and DNA.

Mekkaoui F, Drewell R, Dresch J, Spratt D Biochim Biophys Acta Gene Regul Mech. 2024; 1868(1):195074.

PMID: 39644990 PMC: 11832328. DOI: 10.1016/j.bbagrm.2024.195074.

GHT-SELEX demonstrates unexpectedly high intrinsic sequence specificity and complex DNA binding of many human transcription factors.

Jolma A, Hernandez-Corchado A, Yang A, Fathi A, Laverty K, Brechalov A bioRxiv. 2024; .

PMID: 39605368 PMC: 11601218. DOI: 10.1101/2024.11.11.618478.

Arsenic-induced enhancement of diazotrophic recruitment and nitrogen fixation in Pteris vittata rhizosphere.

Lin J, Dai H, Yuan J, Tang C, Ma B, Xu J Nat Commun. 2024; 15(1):10003.

PMID: 39562570 PMC: 11577039. DOI: 10.1038/s41467-024-54392-x.

Machine learning approaches for biomolecular, biophysical, and biomaterials research.

Rickert C, Lieleg O Biophys Rev (Melville). 2024; 3(2):021306.

PMID: 38505413 PMC: 10914139. DOI: 10.1063/5.0082179.

High-throughput prediction of enzyme promiscuity based on substrate-product pairs.

Xing H, Cai P, Liu D, Han M, Liu J, Le Y Brief Bioinform. 2024; 25(2).

PMID: 38487850 PMC: 10940840. DOI: 10.1093/bib/bbae089.

References
1.
Ptashne M, Backman K, Humayun M, Jeffrey A, Maurer R, Meyer B . Autoregulation and function of a repressor in bacteriophage lambda. Science. 1976; 194(4261):156-61. DOI: 10.1126/science.959843. View
2.
Isobe T, BLACK L, Tsugita A . Protein cleavage during virus assembly: a novel specificity of assembly dependent cleavage in bacteriophage T4. Proc Natl Acad Sci U S A. 1976; 73(11):4205-9. PMC: 431386. DOI: 10.1073/pnas.73.11.4205. View
3.
Wood W, Revel H . The genome of bacteriophage T4. Bacteriol Rev. 1976; 40(4):847-68. PMC: 413987. DOI: 10.1128/br.40.4.847-868.1976. View
4.
Belin D, Hedgpeth J, SELZER G, Epstein R . Temperature-sensitive mutation in the initiation codon of the rIIB gene of bacteriophage T4. Proc Natl Acad Sci U S A. 1979; 76(2):700-4. PMC: 383023. DOI: 10.1073/pnas.76.2.700. View
5.
Yokota T, Sugisaki H, TAKANAMI M, Kaziro Y . The nucleotide sequence of the cloned tufA gene of Escherichia coli. Gene. 1980; 12(1-2):25-31. DOI: 10.1016/0378-1119(80)90012-8. View