Genetics of Hemolysin of Escherichia Coli

Overview

Journal J Bacteriol

Publisher American Society for Microbiology

Specialty Microbiology

Date 1982 Aug 1

PMID 7047487

Citations 27

Authors

S I Hull

R A Hull

B H Minshew

S Falkow

Affiliations

Soon will be listed here.

Abstract

The expression of alpha-hemolysin is a property frequently associated with Escherichia coli extraintestinal infections. We have examined the genetic basis for hemolysin expression by an E. coli strain isolated from a human urinary tract infection. The genes necessary for hemolysin synthesis were found to be chromosomal and to map near the ilv gene cluster. Isogenic hly+ and hly derivatives were also prepared and tested for virulence in the chicken embryo model system. Hemolysin was found to be necessary but not in itself sufficient for E. coli virulence in this in vitro model.

Citing Articles

Characterisation of atypical enteropathogenic E. coli strains of clinical origin.

Tennant S, Tauschek M, Azzopardi K, Bigham A, Bennett-Wood V, Hartland E BMC Microbiol. 2009; 9:117.

PMID: 19490652 PMC: 2700815. DOI: 10.1186/1471-2180-9-117.

Chromosomal regions specific to pathogenic isolates of Escherichia coli have a phylogenetically clustered distribution.

Boyd E, Hartl D J Bacteriol. 1998; 180(5):1159-65.

PMID: 9495754 PMC: 107003. DOI: 10.1128/JB.180.5.1159-1165.1998.

Identification of the O antigen polymerase (rfc) gene in Escherichia coli O4 by insertional mutagenesis using a nonpolar chloramphenicol resistance cassette.

Lukomski S, Hull R, Hull S J Bacteriol. 1996; 178(1):240-7.

PMID: 8550424 PMC: 177645. DOI: 10.1128/jb.178.1.240-247.1996.

Escherichia coli alpha-hemolysin: characteristics and probable role in pathogenicity.

Cavalieri S, Bohach G, Snyder I Microbiol Rev. 1984; 48(4):326-43.

PMID: 6394977 PMC: 373222. DOI: 10.1128/mr.48.4.326-343.1984.

Difference in susceptibility to gram-negative urinary tract infection between C3H/HeJ and C3H/HeN mice.

Hagberg L, Hull R, Hull S, McGhee J, Michalek S, Svanborg Eden C Infect Immun. 1984; 46(3):839-44.

PMID: 6389367 PMC: 261623. DOI: 10.1128/iai.46.3.839-844.1984.

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