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Dominant Mutators in Escherichia Coli

Overview
Journal Genetics
Publisher Oxford University Press
Specialty Genetics
Date 1982 Jan 1
PMID 7047297
Citations 35
Authors
E C Cox
D L Horner
Affiliations
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Abstract

In this paper we report on the isolation and genetic analysis of a series of strong mutators mapping at five minutes on the E. coli chromosome. These mutations are dominant and show no evidence of interaction in merodiploids. Cultures grown in broth medium exhibit mutant frequencies five to six orders of magnitude higher than mut+ strains. Cultures propagated in minimal salts media mutate at rates one to three orders higher than wild-type. Three-factor crosses have been used to order these mutators relative to metD, proA, and a Tn10 insertion near five minutes.

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