Fibrin Deposits in Hodgkin's Disease

Overview

Journal Am J Pathol

Publisher Elsevier

Specialty Pathology

Date 1982 Jul 1

PMID 7046453

Citations 10

Authors

N L Harris

A M Dvorak

J Smith

H F Dvorak

Affiliations

Soon will be listed here.

Abstract

Fibrin deposits were observed in the involved lymph nodes and/or spleens of 15 patients with Hodgkin's disease by specific immunofluorescence and by electron microscopy. Two basic patterns of fibrin deposition were observed: 1) intercellular deposits, chiefly associated with nonneoplastic-appearing lymphoid cells and 2) deposits associated with the collagen fibers of young connective tissue. In addition, coarse fibrin deposits were observed in areas of necrosis, presumably a non-specific finding. Fibronectin was also observed in intercellular areas, but staining was less intense than for fibrin. Fibrin deposits were also observed in 3 of 6 cases of non-Hodgkin's lymphoma, indicating that the finding is not an exclusive feature of Hodgkin's disease. The pathogenesis and possible significance of fibrin deposition in Hodgkin's disease are related to earlier observations of activation of the coagulation system on neoplasia and cell-mediated immunity and to the possible role of fibrin, fibronectin, and their breakdown products in angiogenesis and fibroplasia.

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The distribution of fibronectin in lymph nodes infiltrated by Hodgkin's disease. An immunoperoxidase study on paraffin sections.

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References

LUKES R, Butler J . The pathology and nomenclature of Hodgkin's disease. Cancer Res. 1966; 26(6):1063-83. View

SPAR I, BALE W, MARRACK D, Dewey W, McCARDLE R, Harper P . 131-I-labeled antibodies to human fibrinogen. Diagnostic studies and therapeutic trials. Cancer. 1967; 20(5):865-70. DOI: 10.1002/1097-0142(1967)20:5<865::aid-cncr2820200546>3.0.co;2-5. View

COOPER J, Haq B, Bagnell H . Intrafollicular hyalinosis and arterial hyalinosis of the spleen: histochemical and immunofluorescence studies. J Pathol. 1969; 98(3):193-9. DOI: 10.1002/path.1710980306. View

PETERSON H, ZETTERGREN L . Thromboplastic and fibrinolytic properties of three transplantable rat tumours. Acta Chir Scand. 1970; 136(5):365-8. View

HOLYOKE E, Frank A, WEISS L . Tumor thromboplastic activity in vitro. Int J Cancer. 1972; 9(2):258-63. DOI: 10.1002/ijc.2910090203. View

Variakojis D, Rappaport H . Proteinaceous precipitate in nodular (follicular) lymphomas. Cancer. 1973; 31(3):532-42. DOI: 10.1002/1097-0142(197303)31:3<534::aid-cncr2820310307>3.0.co;2-n. View

Colvin R, Johnson R, Mihm Jr M, Dvorak H . Role of the clotting system in cell-mediated hypersensitivity. I. Fibrin deposition in delayed skin reactions in man. J Exp Med. 1973; 138(3):686-98. PMC: 2139425. DOI: 10.1084/jem.138.3.686. View

DORFMAN R, Rice D, Mitchell A, Kempson R, Levine G . Ultrastructural studies of Hodgkin's disease. Natl Cancer Inst Monogr. 1973; 36:221-38. View

Ruoslahti E, Vaheri A . Novel human serum protein from fibroblast plasma membrane. Nature. 1974; 248(5451):789-91. DOI: 10.1038/248789a0. View

10.

Talerman A, Platenburg H . Follicular lymphoma with deposits of amorphous hyaline material. J Pathol. 1974; 112(1):27-31. DOI: 10.1002/path.1711120106. View

11.

Schlager S, Dray S . Complete local tumor regression with antibody to fibrin Fragment E. J Immunol. 1975; 115(4):976-81. View

12.

AMBRUS J, AMBRUS C, Pickern J, Soldes S, BROSS I . Hematologic changes and thromboembolic complications in neoplastic disease and their relationship to metastasis. J Med. 1975; 6(5-6):433-58. View

13.

Chew E, Wallace A . Demonstration of fibrin in early stages of experimental metastases. Cancer Res. 1976; 36(6):1904-9. View

14.

Glick A, LEECH J, FLEXNER J, Collins R . Ultrastructural study of Reed-Sternberg cells. Comparison with transformed lymphocytes and histiocytes. Am J Pathol. 1976; 85(1):195-208. PMC: 2032544. View

15.

Cattan A, Bresson M . Murine tumor cell activity on in vitro hemostasis. Biomedicine. 1976; 25(7):252-4. View

16.

Sack Jr G, Levin J, Bell W . Trousseau's syndrome and other manifestations of chronic disseminated coagulopathy in patients with neoplasms: clinical, pathophysiologic, and therapeutic features. Medicine (Baltimore). 1977; 56(1):1-37. View

17.

Anagnostou D, Parker J, Taylor C, Tindle B, LUKES R . Lacunar cells of nodular sclerosing Hodgkin's disease: an ultrastructural and immunohistologic study. Cancer. 1977; 39(3):1032-43. DOI: 10.1002/1097-0142(197703)39:3<1032::aid-cncr2820390306>3.0.co;2-x. View

18.

Stenman S, Vaheri A . Distribution of a major connective tissue protein, fibronectin, in normal human tissues. J Exp Med. 1978; 147(4):1054-64. PMC: 2184253. DOI: 10.1084/jem.147.4.1054. View

19.

Gordon S, Lewis B . Comparison of procoagulant activity in tissue culture medium from normal and transformed fibroblasts. Cancer Res. 1978; 38(8):2467-72. View

20.

Stiller D, Katenkamp D . Intercellular substances in Hodgkin's lymphomas. Ultrastructural investigations. Virchows Arch A Pathol Anat Histol. 1978; 380(1):81-90. DOI: 10.1007/BF00432894. View