The Cancer Research Campaign (King's/Cambridge Trial for Early Breast Cancer: Clinico-pathological Aspects

Overview

Journal Br J Cancer

Specialty Oncology

Date 1982 May 1

PMID 7044401

Citations 44

Authors

C W Elston

G A GRESHAM

G S Rao

T ZEBRO

J L Haybittle

J Houghton

G Kearney

Affiliations

Soon will be listed here.

Abstract

Analysis of pathological data in the 10th year of follow-up of a multicentre trial of the management of operable breast cancer has confirmed the correlation of prognosis with tumour grade, tumour size and lymph-node status. For each factor examined there was no difference in survival between the 2 treatment groups ("watch policy" and radiotherapy) but patients in the WP group whose tumours were of Grade II or III or greater than 2 cm, or with lymph-node metastases, had a greater chance of local recurrence. Cellular reaction had no relationship with prognosis, except in patients with Grade III tumours. The clinical relevance and application of these results are discussed.

Citing Articles

Analysis of Spatial Distribution and Prognostic Value of Different Pan Cytokeratin Immunostaining Intensities in Breast Tumor Tissue Sections.

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PMID: 32580421 PMC: 7352516. DOI: 10.3390/ijms21124434.

Size and Shape Filtering of Malignant Cell Clusters within Breast Tumors Identifies Scattered Individual Epithelial Cells as the Most Valuable Histomorphological Clue in the Prognosis of Distant Metastasis Risk.

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Clinicopathological characteristics of infiltrating lobular breast carcinoma in elderly women: Preliminary results.

Ruibal A, Aguiar P, Del Camen Del Rio M, Menendez P, Arias J, Herranz M Mol Clin Oncol. 2016; 3(6):1337-1340.

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Effect of specialized diagnostic assessment units on the time to diagnosis in screen-detected breast cancer patients.

Jiang L, Gilbert J, Langley H, Moineddin R, Groome P Br J Cancer. 2015; 112(11):1744-50.

PMID: 25942395 PMC: 4647239. DOI: 10.1038/bjc.2015.147.

Computer-based image studies on tumor nests mathematical features of breast cancer and their clinical prognostic value.

Wang L, Qu A, Yuan J, Chen C, Sun S, Hu M PLoS One. 2013; 8(12):e82314.

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