Ultrastructural Features of the Multiplication of Human and Murine Leprosy Bacilli in Macrophages of Nude Mice

Overview

Journal Int J Lepr Other Mycobact Dis

Specialties Microbiology
Tropical Medicine

Date 1982 Mar 1

PMID 7042613

Citations 4

Authors

Y Fukunishi

S Okada

M Nishiura

K Kohsaka

Affiliations

Soon will be listed here.

Abstract

Ultrastructural features of the growth of M. leprae and M. lepraemurium in nude mouse macrophages were studied by ultrathin sectioning and freeze-etching. In nude mouse macrophages, M. leprae produced spherical droplets (foamy structures) similar to those in human lepra cells. On the other hand, M. lepraemurium produced typical crystalline material in nude mouse macrophages, which is quite the same as that observed in the C3H strain mouse, Spherical droplets in the form of foamy structures seem to be made up of a specific substance produced by the multiplication of M. leprae in suitable host cells (human, nude mouse, and armadillo macrophages).

Citing Articles

Activities of fluoroquinolone, macrolide, and aminoglycoside drugs combined with inhibitors of glycosylation and fatty acid and peptide biosynthesis against Mycobacterium avium.

Barrow W, Wright E, Goh K, Rastogi N Antimicrob Agents Chemother. 1993; 37(4):652-61.

PMID: 8494359 PMC: 187730. DOI: 10.1128/AAC.37.4.652.

Study on the micromorphology of Mycobacterium leprae.

Burchard G, Bierther M Arch Dermatol Res. 1985; 277(3):220-4.

PMID: 3893332 DOI: 10.1007/BF00404320.

Modified lymphocyte response to mitogens after intraperitoneal injection of glycopeptidolipid antigens from Mycobacterium avium complex.

Brownback P, Barrow W Infect Immun. 1988; 56(5):1044-50.

PMID: 3258582 PMC: 259759. DOI: 10.1128/iai.56.5.1044-1050.1988.

Biological, chemical, immunological and staining properties of bacteria isolated from tissues of leprosy patients.

Cocito C, DELVILLE J Eur J Epidemiol. 1985; 1(3):202-31.

PMID: 2429862 DOI: 10.1007/BF00234095.