X-linked Genes of the H-Y Antigen System in the Wood Lemming (Myopus Schisticolor)

Overview

Journal Hum Genet

Specialty Genetics

Date 1982 Jan 1

PMID 7042534

Citations 12

Authors

U Wiberg

A MAYEROVA

U Muller

K Fredga

U Wolf

Affiliations

Soon will be listed here.

Abstract

H-Y antigen was investigated in 18 specimens representing six different sex chromosome constitutions of the wood lemming (Myopus schisticolor). The control range of H-Y antigen was defined by the sex difference between normal XX females (H-Y negative per definitionem) and normal XY males (H-Y positive, full titer). H-Y antigen titers of the X*Y and X*0 females were in the male control range, while in the X*X and X0 females the titers were intermediary. Data were obtained with two different H-Y antigen assays: the Raji cell cytotoxicity test and the peroxidase-antiperoxidase (PAP) method. Fibroblasts, gonadal cells, and spleen cells were checked. Presence of full titers of H-Y antigen in the absence of testis differentiation is readily explained by the assumption of a deficiency of the gonad-specific receptor of H-Y antigen. Since sex reversal is inherited as an X-linked trait, genes for this receptor are most likely X-linked. The implications of our findings are discussed in connection with earlier findings concerning H-Y antigen in XY gonadal dysgenesis in man and the X0 situation in man and mouse.

Citing Articles

Identification and function of serologically detectable H-Y antigen.

Muller U Hum Genet. 1982; 61(2):91-4.

PMID: 7129449 DOI: 10.1007/BF00274193.

Genetic homology and crossing over in the X and Y chromosomes of Mammals.

Burgoyne P Hum Genet. 1982; 61(2):85-90.

PMID: 7129448 DOI: 10.1007/BF00274192.

Genetic control of H-Y synthesis. A hypothesis.

Adinolfi M, Polani P, Zenthon J Hum Genet. 1982; 61(1):1-2.

PMID: 6751986 DOI: 10.1007/BF00291320.

The X linked recessive form of XY gonadal dysgenesis with a high incidence of gonadal germ cell tumours: clinical and genetic studies.

Mann J, Corkery J, FISHER H, Cameron A, MAYEROVA A, Wolf U J Med Genet. 1983; 20(4):264-70.

PMID: 6620326 PMC: 1049117. DOI: 10.1136/jmg.20.4.264.

Absence of H-Y antigen in a case of sporadic pure gonadal dysgenesis.

Boucekkine C, BENMILOUD M, Himeur B, Chouiter A, Bachammar M J Endocrinol Invest. 1984; 7(3):225-30.

PMID: 6432892 DOI: 10.1007/BF03348428.

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