Substrate Utilization in the Myocardium

Overview

Journal Basic Res Cardiol

Specialty Cardiology & Vascular Diseases

Date 1982 Jan 1

PMID 7041882

Citations 4

Authors

A J Drake

Affiliations

Soon will be listed here.

Abstract

Substrate extraction is the disappearance of a substance from arterial blood into the myocardium, substrate utilization being the combustion of that substrate. The terms used for extraction and utilization are defined. There are many problems of accurately measuring glucose and free fatty acid oxidation. Lactate is the preferred substrate of the normal, blood-perfused heart. If the substrate oxidized affects the myocardial oxygen consumption, this could be of considerable importance under conditions of limited oxygen supply. At present there is conflicting evidence. It may be beneficial to switch the heart from one substrate to another, e.g., from fat to carbohydrate fuels. The conditions of ischaemia and hypoxaemia are not the same, and future investigations should be made under carefully controlled conditions.

Citing Articles

Lactate as substrate for mitochondrial respiration in alveolar epithelial type II cells.

Lottes R, Newton D, Spyropoulos D, Baatz J Am J Physiol Lung Cell Mol Physiol. 2015; 308(9):L953-61.

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Substrate selection in the isolated working rat heart: effects of reperfusion, afterload, and concentration.

Jeffrey F, Diczku V, Sherry A, Malloy C Basic Res Cardiol. 1995; 90(5):388-96.

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31P magnetic resonance spectroscopy of the Sherpa heart: a phosphocreatine/adenosine triphosphate signature of metabolic defense against hypobaric hypoxia.

Hochachka P, Clark C, Holden J, Stanley C, Ugurbil K, Menon R Proc Natl Acad Sci U S A. 1996; 93(3):1215-20.

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Cardiac efficiency.

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