Antibacterial Kinetics of Ampicillin Against Escherichia Coli Under Simulated in Vivo Conditions

Overview

Journal Infection

Date 1982 Jan 1

PMID 7040252

Citations 3

Authors

J E Fuglesang

T Bergan

Affiliations

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Abstract

We studied the response of Escherichia coli to ampicillin concentrations which decreased logarithmically at elimination half-life values (t1/2a) ranging from one to four hours. The rate of bacterial killing depended on the initial antibiotic concentration (co), but was not significantly affected by t1/2a. Irrespective of co and t1/2a, the bactericidal effect terminated after about three hours of exposure to the drug.

Citing Articles

Antibacterial activity and kill kinetics of amoxicillin-clavulanic acid combinations against Escherichia coli and Klebsiella aerogenes.

Fuglesang J, Bergan T Infection. 1983; 11(6):329-35.

PMID: 6365790 DOI: 10.1007/BF01641359.

Antibacterial activity and kill kinetics of ampicillin/sulbactam (CP-45899) combinations against Escherichia coli and Klebsiella aerogenes.

Fuglesang J, Bergan T Infection. 1984; 12(1):46-50.

PMID: 6323321 DOI: 10.1007/BF01641025.

Inhibitory activity and bactericidal kinetics of mecillinam/ampicillin combinations against Enterobacteriaceae, Pseudomonas and Acinetobacter.

Fuglesang J, Bergan T, Bielecki T, Naterstad A, Namork E Infection. 1981; 9(6):290-5.

PMID: 6277795 DOI: 10.1007/BF01640994.

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