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Hormonal Requirements for Growth of Arterial Smooth Muscle Cells in Vitro: and Endocrine Approach to Atherosclerosis

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Journal Science
Specialty Science
Date 1981 May 15
PMID 7013068
Citations 19
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Abstract

In this study the hormonal requirements for the growth of arterial smooth muscle cells in vitro were determined. A serum-free, biochemically defined medium, supplemented with the relevant hormones, permitted proliferation and propagation of normal diploid mammalian arterial smooth muscle cells. Serum-free, hormone-supplemented cultures spontaneously formed atherosclerotic plaque-like nodules. Thus atherosclerosis may be mediated by a complex endocrine system.

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