Macrophage Antimicrobial Activity: Evidence for Participation by Lysosomes in the Killing of Saccharomyces Cerevisiae by Normal Resident Macrophages

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1981 Feb 1

PMID 7012023

Citations 4

Authors

P D HART

Affiliations

Soon will be listed here.

Abstract

Ammonium chloride added to normal resident mouse peritoneal macrophages reduced the rate of killing of ingested Saccharomyces cerevisiae. It is suggested that this is attributable to the inhibition by ammonia of phagosome-lysosome fusion or of lysosomal protein degradation and that, consequently, lysosomal mechanisms contribute to the normal killing of these yeasts.

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