Influence of Complement on the Chemiluminescent Response of Human Leukocytes to Immune Complex

Overview

Journal Infect Immun

Publisher American Society for Microbiology

Specialty Allergy & Immunology

Date 1980 Aug 1

PMID 7011971

Citations 8

Authors

S Lofgren

A Tarnvik

J Carlsson

Affiliations

Soon will be listed here.

Abstract

Vaccine bacteria of Francisella tularensis were mixed with human serum containing specific antibodies against the same organism, and the mixture was incubated at 37 degrees C for 30 min. The mixture induced a two-peak chemiluminescent response in polymorphonuclear leukocytes. The initial peak was induced by a soluble agent, formed during incubation. The formation of this agent involved the activation of complement component C5. The second peak of the chemiluminescent response was induced by the opsonized bacteria; this peak was augmented by complement component C3, whereas C5 had no influence.

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Demonstration of opsonizing antibodies to Francisella tularensis by leukocyte chemiluminescence.

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