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Gonadotropin Releasing Hormone Agonists Stimulate Oocyte Meiosis and Ovulation in Hypophysectomized Rats

Overview
Journal Endocrinology
Publisher Oxford University Press
Specialty Endocrinology
Date 1981 May 1
PMID 7011791
Citations 8
Authors
C Ekholm
T Hillensjo
O Isaksson
Affiliations
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Abstract

The acute effects in vivo of gonadotropin releasing hormone (GnRH) and a potent agonistic analogue (GnRHa) were tested in PMSG-treated immature female rats, hypophysectomized on the morning of proestrus. The rats were injected once with either LH, GnRH, or GnRHa 3-4 h after surgery, and the effects on oocyte meiosis, ovulation, and plasma progesterone were investigated. LH (25 microgram) and GnRHa (12.0 and 1.2 microgram) caused a high rate of meiosis, while GnRH (100 microgram) or GnRHa (0.12 microgram) caused a partial response. LH and GnRHa produced ovulation in all of the treated rats and caused a prolonged increase in plasma progesterone levels. It is concluded that GnRH agonists exert acute stimulatory effects in the ovarian follicle, independent of pituitary factors.

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