Extracorporeal Immunoadsorption of Myeloma IgG and Autoimmune Antibodies: a Clinically Feasible Modality of Treatment

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1980 Nov 1

PMID 7008987

Citations 2

Authors

P K Ray

E Besa

A Idiculla

J E RHOADS Jr

J G Bassett

D R Cooper

Affiliations

Soon will be listed here.

Abstract

Using heat-killed, formalin-stabilized Staphylococcus aureus Cowan I suspension, it was possible to remove myeloma IgG and autoimmune anti-red blood cell antibodies from two patients' plasma following an extracorporeal procedure. The arterial anticoagulated blood was processed through a cell separator machine. The separated plasma was pumped through a bacterial filter containing S. aureus suspension. The adsorbed plasma was then reunited with the blood cells and returned to the patient through the vein. S. aureus Cowan I could selectively remove the myeloma IgG and autoimmune anti-red cell antibodies from the patients' plasma prolonging the lives of these two terminal patients. The immunoadsorption procedure appears to be a safe, practical and quick method for the removal of pathological IgG from the patients' plasma.

Citing Articles

Exogenous supplementation of -acetylcysteine Can Reduce Hepatotoxicity Induced by Ascites Fluid (Cell-Free) Adsorbed Over Protein-A-Containing Cowan-I Without Compromising Its Antitumor Effect.

Verma A, Mallick P, Dwivedi P, Singh A J Pharm Bioallied Sci. 2019; 11(3):205-215.

PMID: 31555026 PMC: 6662038. DOI: 10.4103/jpbs.JPBS_216_18.

Cysteine Supplementation Mitigates the Toxicity Associated with Antitumor Therapy of Ehrlich's Ascites Fluid Adsorbed over Protein A Containing Cowan I.

Verma A, Singh A, Mallick P, Dwivedi P J Pharm Bioallied Sci. 2019; 11(1):23-32.

PMID: 30906136 PMC: 6394159. DOI: 10.4103/jpbs.JPBS_108_18.

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