Hidden Thy-1 Antigen in a Subpopulation of Mouse Bone Marrow Cells

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1980 Mar 1

PMID 7002765

Citations 7

Authors

M A Ritter

R J Morris

I Goldschneider

Affiliations

Soon will be listed here.

Abstract

Immunofluorescence and cytolysis studies using antisera against the xeno- and alloantigenic components of the Thy-1 molecule have shown that in adult mouse bone marrow more cells bear the xeno than the alloantigen. Allo+ cells form a subset of a larger, xeno+ population. Xeno+ allo- 'prothymocytes' can be induced to express the alloantigen in vitro; this could result from the unmasking of cryptic antigen, the presence of which is demonstrated, rather than de novo antigen synthesis. Some xeno+ allo- cells are involved in splenic haemopoiesis, either as a subpopulation of precursors, or as accessory helper cells.

Citing Articles

Association of thy-1 cell surface differentiation antigen with certain connective tissues in vivo.

Morris R, Ritter M Cell Tissue Res. 1980; 206(3):459-75.

PMID: 7388902 DOI: 10.1007/BF00237975.

Analysis of rat hemopoietic cells on the fluorescence-activated cell sorter. I. Isolation of pluripotent hemopoietic stem cells and granulocyte-macrophage progenitor cells.

Goldschneider I, Metcalf D, Battye F, Mandel T J Exp Med. 1980; 152(2):419-37.

PMID: 6995554 PMC: 2185949. DOI: 10.1084/jem.152.2.419.

Expression of Thy-1 antigen is not limited to T cells in cultures of mouse hemopoietic cells.

Schrader J, Battye F, Scollay R Proc Natl Acad Sci U S A. 1982; 79(13):4161-5.

PMID: 6125942 PMC: 346597. DOI: 10.1073/pnas.79.13.4161.

Sequential activation and loss of the pre-B cell Thy-1 gene in T-cell X pre-B cell somatic hybrids.

HYMAN R, Clarkin K Immunogenetics. 1988; 27(5):313-21.

PMID: 2895732 DOI: 10.1007/BF00395126.

Differential regulation of a Thy-1 gene in transgenic mice.

Kollias G, Spanopoulou E, Grosveld F, Ritter M, Beech J, Morris R Proc Natl Acad Sci U S A. 1987; 84(6):1492-6.

PMID: 2882505 PMC: 304460. DOI: 10.1073/pnas.84.6.1492.

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