Identification of Cells Expressing T and P28,33 (Ia-like) Antigens in Sections of Human Lymphoid Tissue

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1980 Jan 1

PMID 6993067

Citations 6

Authors

G J Seymour

M F Greaves

G Janossy

Affiliations

Soon will be listed here.

Abstract

A method has been developed for identifying human lymphocyte populations in tissue sections using hetero-antisera to T cells and to the B cell associated Ia-like, p28,33 polypeptide complex. The differential topographical localisation of T and B cells is revealed by simultaneous staining with antibodies tagged with different fluorochromes; this approach also identifies a small population of T cells bearing Ia-like antigens. Preliminary studies on lymphomatous tissue suggests this approach will be of value in the study of malignancy and cellular infiltration in disease.

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