Islet-cell Antibodies and Beta-cell Function in Insulin-dependent Diabetics

Overview

Journal Diabetologia

Specialty Endocrinology

Date 1980 Jan 1

PMID 6988264

Citations 8

Authors

S Madsbad

G F Bottazzo

A G Cudworth

B Dean

O K Faber

C Binder

Affiliations

Soon will be listed here.

Abstract

Residual insulin secretion and islet-cell antibodies were studied in 399 insulin-dependent diabetics with age at onset of between 10--19.9 years (248 patients) or 30--39.9 years (151 patients). We found the prevalence of islet-cell antibodies to be independent of residual beta-cell function as measured by serum C-peptide and age at onset. The cause and role of the persistence of islet-cell antibodies in insulin-dependent diabetics remain obscure.

Citing Articles

Analysis of insulin in human breast milk in mothers with type 1 and type 2 diabetes mellitus.

Whitmore T, Trengove N, Graham D, Hartmann P Int J Endocrinol. 2012; 2012:296368.

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Genetics of Type I diabetes mellitus: a single, recessive predisposition gene mapping between HLA-B and GLO. With an appendix on the estimation of selection bias.

Rubinstein P, Ginsberg-Fellner F, Falk C Am J Hum Genet. 1981; 33(6):865-82.

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Evidence of delayed beta-cell destruction in type 1 (insulin-dependent) diabetic patients with persisting complement-fixing cytoplasmic islet cell antibodies.

Mustonen A, Knip M, Huttunen N, Puukka R, Kaar M, Akerblom H Diabetologia. 1984; 27(4):421-6.

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Beta-cell damage in diabetic insulitis: are we approaching a solution?.

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Analysis of islet cell antibodies on frozen sections of human pancreas.

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