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Silicone Rubber Substrata: a New Wrinkle in the Study of Cell Locomotion

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Journal Science
Specialty Science
Date 1980 Apr 11
PMID 6987736
Citations 383
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Abstract

When tissue cells are cultured on very thin sheets of cross-linked silicone fluid, the traction forces the cells exert are made visible as elastic distortion and wrinkling of this substratum. Around explants this pattern of wrinkling closely resembles the "center effects" long observed in plasma clots and traditionally attributed to dehydration shrinkage.

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