Treatment of Cutaneous T-cell Lymphoma with a New Aromatic Retinoid (Ro 10-9359)

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1982 Jan 1

PMID 6985201

Authors

A L Claudy

Y DELOMIER

C HERMIER

Affiliations

Soon will be listed here.

Abstract

A 77-year-old woman developed a diffuse nodular eruption with histologic, ultrastructural, and biologic evidence of cutaneous T-cell lymphoma (CTCL) limited to the skin. She was treated with a new aromatic retinoid Ro 10-9359 (1 mg/kg/day). After 34 days, the lesions flattened completely and the mononuclear cell infiltrate decreased significantly. No clinical recurrences occurred after a 4-month survey. Discontinuation of the aromatic retinoid led to a relapse with identical clinical and histologic features.

References

Elias P, Williams M . Retinoids, cancer, and the skin. Arch Dermatol. 1981; 117(3):160-8. View

Lassus A . Systemic treatment of psoriasis with an oral retinoic acid derivative (Ro 10-9359). Br J Dermatol. 1980; 102(2):195-202. DOI: 10.1111/j.1365-2133.1980.tb05692.x. View

Schnitzler L, Schubert B, Verret J . [Evaluation of oral retinoid preventive action on human cutaneous epitheliomas (author's transl)]. Ann Dermatol Venereol. 1980; 107(7):657-63. View

FREDRIKSSON T . Oral treatment of psoriasis and pustulosis palmo-plantaris with Ro 10-9359. Dermatologica. 1978; 157 Suppl 1:13-8. DOI: 10.1159/000250879. View

VAN SCOTT E, Kalmanson J . Complete remissions of mycosis fungoides lymphoma induced by topical nitrogen mustard (HN2). Control of delayed hypersensitivity to HN2 by desensitization and by induction of specific immunologic tolerance. Cancer. 1973; 32(1):18-30. DOI: 10.1002/1097-0142(197307)32:1<18::aid-cncr2820320103>3.0.co;2-q. View

BOLLAG W . Therapeutic effects of an aromatic retinoic acid analog on chemically induced skin papillomas and carcinomas of mice. Eur J Cancer (1965). 1974; 10(11):731-7. DOI: 10.1016/0014-2964(74)90112-1. View

BOLLAG W, Ott F . Vitamin A acid in benign and malignant epithelial tumours of the skin. Acta Derm Venereol Suppl (Stockh). 1975; 74:163-6. View

Orfanos C, Kurka M, Strunk V . Oral treatment of keratosis follicularis with a new aromatic retinoid. Arch Dermatol. 1978; 114(8):1211-4. View

Guilhou J, Malbos S, Meynadier J . [Oral treatment of severe psoriasis with a new aromatic retinoid (Ro 10-9359) (author's transl)]. Ann Dermatol Venereol. 1978; 105(10):813-8. View

10.

Mayer H, BOLLAG W, Hanni R, RUEGG R . Retinoids, a new class of compounds with prophylactic and therapeutic activities in oncology and dermatology. Experientia. 1978; 34(9):1105-19. DOI: 10.1007/BF01922901. View

11.

Lauharanta J . Retinoids in the treatment and prevention of dermatoses and epithelial neoplasias. Ann Clin Res. 1980; 12(3):123-30. View

12.

Ryssel H, BRUNNER K, BOLLAG W . [The oral administration of vitamin-A-acid in leukoplakias, hyperkeratoses and squamous cell carcinomas: results and tolerance]. Schweiz Med Wochenschr. 1971; 101(28):1027-30. View

13.

Schuppli R . The efficacy of a new retinoid (Ro 10-9359) in lichen planus. Dermatologica. 1978; 157 Suppl 1:60-3. DOI: 10.1159/000250888. View

14.

FREDRIKSSON T, Pettersson U . Severe psoriasis--oral therapy with a new retinoid. Dermatologica. 1978; 157(4):238-44. DOI: 10.1159/000250839. View

15.

Sporn M, Newton D . Chemoprevention of cancer with retinoids. Fed Proc. 1979; 38(11):2528-34. View

16.

Thune P, Mork N . A case of centrolobular toxic necrosis of the liver due to aromatic retinoid--Tigason (Ro 10-9359). Dermatologica. 1980; 160(6):405-8. DOI: 10.1159/000250532. View

17.

Weeks C, Slaga T, Hennings H, Gleason G, Bracken W . Inhibition of phorbol ester-induced tumor promotion in mice by vitamin A analog and anti-inflammatory steroid. J Natl Cancer Inst. 1979; 63(2):401-6. View

18.

Fuks Z, Bagshaw M, Farber E . Prognostic signs and the management of the mycosis fungoides. Cancer. 1973; 32(6):1385-95. DOI: 10.1002/1097-0142(197312)32:6<1385::aid-cncr2820320617>3.0.co;2-#. View

19.

Orfanos C . Oral retinoids--present status. Br J Dermatol. 1980; 103(5):473-81. DOI: 10.1111/j.1365-2133.1980.tb01661.x. View

20.

Gilchrest B, Parrish J, Tanenbaum L, Haynes H, Fitzpatrick T . Oral methoxsalen photochemotherapy of mycosis fungoides. Cancer. 1976; 38(2):683-9. DOI: 10.1002/1097-0142(197608)38:2<683::aid-cncr2820380210>3.0.co;2-v. View