Functional Assessment of T and B Lymphocytes in Patients with Selective IgM Deficiency

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1982 Sep 1

PMID 6983403

Citations 14

Authors

E G de la Concha

M C Garcia-Rodriguez

J M Zabay

M T Laso

F Alonso

A Bootello

G Fontan

Affiliations

Soon will be listed here.

Abstract

Two patients with selective IgM deficiency were studied. Both presented with dermatitis, chronic diarrhoea, recurrent respiratory infections, failure to thrive, elevated serum IgE levels and in vivo impairment of antibody production. No phagocytic or complement abnormalities were found. B lymphocytes with surface IgM were present in normal or high percentage in peripheral blood, and produced normal amounts of IgM in vitro when co-cultured with normal T cells. Patients' T cells did not show excess suppressor function in vitro but had a decreased helper activity for IgM, IgG and IgA production. It is suggested that both patients have an extensive humoral immune deficiency that might be caused by the immunoregulatory T cell defect.

Citing Articles

Selective IgM Deficiency: Evidence, Controversies, and Gaps.

Taietti I, Votto M, De Filippo M, Naso M, Montagna L, Montagna D Diagnostics (Basel). 2023; 13(17).

PMID: 37685399 PMC: 10486670. DOI: 10.3390/diagnostics13172861.

Skin Manifestations in Patients with Selective Immunoglobulin E Deficiency.

Picado C, Garcia-Herrera A, Hernandez-Rodriguez J, Vlagea A, Pascal M, Bartra J J Clin Med. 2022; 11(22).

PMID: 36431272 PMC: 9694019. DOI: 10.3390/jcm11226795.

Selective immunoglobulin M deficiency complicated by systemic lupus erythematosus and antiphospholipid syndrome: a case report and review of literature.

Shimamura Y, Maeda T, Abe K, Ogawa Y, Takizawa H CEN Case Rep. 2021; 10(3):435-441.

PMID: 33616883 PMC: 8271070. DOI: 10.1007/s13730-021-00583-0.

Comprehensive clinical and immunological features of 62 adult patients with selective primary IgM deficiency.

Lucuab-Fegurgur D, Gupta S Am J Clin Exp Immunol. 2020; 8(6):55-67.

PMID: 31970029 PMC: 6971419.

Defining Primary Selective IgM Deficiency.

Gupta S, Gupta A J Clin Immunol. 2019; 39(4):350-352.

PMID: 31073845 DOI: 10.1007/s10875-019-00641-4.

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