The Absence of Circulating Immune Complexes in Patients with Ankylosing Spondylitis

Overview

Journal Rheumatol Int

Specialty Rheumatology

Date 1981 Jan 1

PMID 6981182

Citations 2

Authors

W Maksymowych

M K Dasgupta

R S Rothwell

J B Dossetor

A S Russell

Affiliations

Soon will be listed here.

Abstract

Sera from 50 patients with well-defined ankylosing spondylitis were examined for circulating immune complexes using both a Clq binding (fluid phase) assay and a Raji cell assay. No more than five of the patients assessed had circulating immune complexes by either one of these techniques and none were positive in both. This result is in contrast to the high prevalence in sera from unselected patients with rheumatoid arthritis and systemic lupus used as positive controls.

Citing Articles

Relation of microscopic haematuria in ankylosing spondylitis to circulating IgA containing immune complexes.

Peeters A, van den Wall Bake A, van Dalsen A, Westedt M Ann Rheum Dis. 1988; 47(8):645-7.

PMID: 3415363 PMC: 1006715. DOI: 10.1136/ard.47.8.645.

Immune complexes in ankylosing spondylitis.

MacLean I, Archer J, Cawley M, Kidd B, OHara B, Pegley F Ann Rheum Dis. 1992; 51(1):83-6.

PMID: 1540045 PMC: 1004625. DOI: 10.1136/ard.51.1.83.

References

Veys E, van Leare M . Serum IgG, IgM, and IgA levels in ankylosing spondylitis. Ann Rheum Dis. 1973; 32(6):493-6. PMC: 1006157. DOI: 10.1136/ard.32.6.493. View

Arana R, de la Vega M, Porrini A, GARCIA MORTEO O . Antiglobulins in ankylosing spondylitis. J Rheumatol. 1975; 2(3):303-7. View

Whaley K, Canesi B, Moseley A, Morrow W, Sturrock R, Mitchell W . Complement metabolism in the seronegative arthritides. Ann Rheum Dis. 1974; 33(6):495-9. PMC: 1006314. DOI: 10.1136/ard.33.6.495. View

Johny K, Dasgupta M, Nakashima S, Dossetor J . Three polyethylene glycol dependent methods for the detection or circulating immune complexes in pathological sera: comparison with the Raji cell method. J Immunol Methods. 1981; 40(1):61-71. DOI: 10.1016/0022-1759(81)90080-6. View

Eghtedari A, Davis P, Bacon P . Immunological reactivity in ankylosing spondylitis. Circulating immunoblasts, autoantibodies, and immunoglobulins. Ann Rheum Dis. 1976; 35(2):155-7. PMC: 1006528. DOI: 10.1136/ard.35.2.155. View

Torrigiani G, Roitt I . Antiglobulin factors in sera from patients with rheumatoid arthritis and normal subjects. Quantitative estimation in different immunoglobulin classes. Ann Rheum Dis. 1967; 26(4):334-40. PMC: 1031069. DOI: 10.1136/ard.26.4.334. View

Kinsella T, Espinoza L, Vasey F . Serum complement and immunoglobulin levels in sporadic and familial ankylosing spondylitis. J Rheumatol. 1975; 2(3):308-13. View

Rosenbaum J, Theofilopoulos A, McDevitt H, Pereira A, Carson D, Calin A . Presence of circulation immune complexes in Reiter's syndrome and ankylosing spondylitis. Clin Immunol Immunopathol. 1981; 18(2):291-7. DOI: 10.1016/0090-1229(81)90036-2. View

Gabay R, Zubler R, Nydegger U, Lambert P . Immune complexes and complement catabolism in ankylosing spondylitis. Arthritis Rheum. 1977; 20(4):913-6. DOI: 10.1002/art.1780200402. View

10.

Julkunen H . Synovial inflammatory cell reaction in chronic arthritis. Acta Rheumatol Scand. 1966; 12(3):188-96. DOI: 10.3109/rhe1.1966.12.issue-1-4.22. View

11.

Zubler R, Nydegger U, Perrin L, Fehr K, McCormick J, Lambert P . Circulating and intra-articular immune complexes in patients with rheumatoid arthritis. Correlation of 125I-Clq binding activity with clinical and biological features of the disease. J Clin Invest. 1976; 57(5):1308-19. PMC: 436784. DOI: 10.1172/JCI108399. View

12.

Corrigall V, Panayi G, Unger A, Poston R, Williams B . Detection of immune complexes in serum of patients with ankylosing spondylitis. Ann Rheum Dis. 1978; 37(2):159-63. PMC: 1001182. DOI: 10.1136/ard.37.2.159. View

13.

Kendall M, Farr M, MEYNELL M, HAWKINS C . Synovial fluid in ankylosing spondylitis. Ann Rheum Dis. 1973; 32(6):487-92. PMC: 1006156. DOI: 10.1136/ard.32.6.487. View

14.

Duquesnoy B, Santoro F, Wattre P, Delcambre B . Failure to find C1q-binding material and anti-IgG antibodies in ankylosing spondylitis. Ann Rheum Dis. 1980; 39(5):449-52. PMC: 1000583. DOI: 10.1136/ard.39.5.449. View