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Rapid Detection in Spinal Fluid of Beta-lactamase Produced by Ampicillin-resistant Haemophilus Influenzae

Overview
Journal J Clin Microbiol
Specialty Microbiology
Date 1982 Jun 1
PMID 6980897
Citations 5
Authors
W H Boughton
Affiliations
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Abstract

The chromogenic cephalosporin nitrocefin was used to detect the presence of beta-lactamase in cerebrospinal fluid of patients suffering from ampicillin-resistant Haemophilus influenzae meningitis. Five samples of spinal fluid containing ampicillin-resistant isolates were studied, and all had beta-lactamase activity. When samples of spinal fluid containing 33 ampicillin-sensitive isolates and 234 sterile specimens were tested, no beta-lactamase activity was detected.

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