Genetic Control of T-lymphocyte Mitogenesis in Chickens

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1981 Jan 1

PMID 6974136

Citations 5

Authors

P R Morrow

H Abplanalp

Affiliations

Soon will be listed here.

Abstract

The in vitro mitogenic response to PHA and Con A was determined in three inbred lines of chickens. Lymphocytes from one line consistently showed a greater stimulation by PHA than the other two lines. Analysis of F1 crosses and backcrosses indicated that this quantitative difference was controlled by more than one gene. More substantial differences in Con-A stimulation were also observed between the three lines, and the data indicated that separate genetic systems were controlling the variation in PHA and Con-A stimulation. Analysis of F1 crosses, backcrosses and assortative matings between backcrosses revealed that the variation in Con-A stimulation was controlled by at least two major genes, one of which may be linked to the major histocompatibility complex. Surprisingly, one line appeared to be segregating for Con-A stimulation in spite of an inbreeding coefficient greater than 0.98.

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Analysis of the B-G antigens of the chicken MHC by two-dimensional gel electrophoresis.

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Physical linkage of a guanine nucleotide-binding protein-related gene to the chicken major histocompatibility complex.

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