HLA DR4 and Rheumatoid Arthritis in Japanese People

Overview

Journal Ann Rheum Dis

Specialty Rheumatology

Date 1981 Jun 1

PMID 6972742

Citations 15

Authors

H Maeda

T Juji

H Mitsui

H Sonozaki

K Okitsu

Affiliations

Soon will be listed here.

Abstract

Eighty-eight Japanese patients with rheumatoid arthritis and 104 normal Japanese persons were typed for HLA A, B, C, and DR antigens. The frequency of HLA DR4 was 70.5% in patients compared with 46.1% in normal controls (P less than 0.001). However, a sex difference in the frequency of HLA DR4 in patients was noted. HLA DR4 was found in 80.6% of male patients, which was highly significant compared with controls (P less than 0.0005), while only a borderline increase of 60.5% was found in female patients (P less than 0.05). In addition, the frequency of HLA DR2 was remarkably low in male patients. These suggest the possible heterogeneity of rheumatoid arthritis in Japanese.

Citing Articles

Rheumatoid Arthritis Accompanying Diffuse Panbronchiolitis.

Isono T, Shibata S, Matsui Y, Hosoda C, Kawabata Y, Shimizu Y Intern Med. 2021; 60(23):3779-3783.

PMID: 34148951 PMC: 8710394. DOI: 10.2169/internalmedicine.6915-20.

Ethnicity may be a reason for lipid changes and high Lp(a) levels in rheumatoid arthritis.

Cesur M, Ozbalkan Z, Temel M, Karaarslan Y Clin Rheumatol. 2006; 26(3):355-61.

PMID: 16680389 DOI: 10.1007/s10067-006-0303-5.

Rheumatoid arthritis associated with ulcerative colitis.

Adachi Y, Hinoda Y, Takahashi H, Nakagawa N, Sakamoto H, Itoh F J Gastroenterol. 1996; 31(4):590-5.

PMID: 8844484 DOI: 10.1007/BF02355063.

Investigation of the HLA component involved in rheumatoid arthritis (RA) by using the marker association-segregation chi-square (MASC) method: rejection of the unifying-shared-epitope hypothesis.

Dizier M, Eliaou J, Babron M, Combe B, Sany J, Clot J Am J Hum Genet. 1993; 53(3):715-21.

PMID: 7688934 PMC: 1682405.

Lack of HLA-antigen association in Greek rheumatoid arthritis patients.

Papasteriades C, Kappou I, Skopouli F, Barla M, Fostiropoulos G, Moutsopoulos H Rheumatol Int. 1985; 5(5):201-3.

PMID: 3865340 DOI: 10.1007/BF00541336.

References

Maeda H, Takeuchi F, Juji T, Akanuma Y, Kasuga M, Lee Y . HLA-DRw3 in juvenile onset diabetes mellitus in Chinese. Tissue Antigens. 1980; 15(2):173-6. DOI: 10.1111/j.1399-0039.1980.tb00901.x. View

Lies R, Messner R, TROUP G . Histocompatibility antigens and rheumatoid arthritis. Arthritis Rheum. 1972; 15(5):524-9. DOI: 10.1002/art.1780150508. View

Kueppers F, Brackertz D, MUELLER-ECKHARDT C . HL-A antigens in sarcoidosis and rheumatoid arthritis. Lancet. 1972; 2(7792):1425. DOI: 10.1016/s0140-6736(72)93004-8. View

Schlosstein L, Terasaki P, Bluestone R, Pearson C . High association of an HL-A antigen, W27, with ankylosing spondylitis. N Engl J Med. 1973; 288(14):704-6. DOI: 10.1056/NEJM197304052881403. View

Morris R, Metzger A, Bluestone R, Terasaki P . HL-A W27--a clue to the diagnosis and pathogenesis of Reiter's syndrome. N Engl J Med. 1974; 290(10):554-6. DOI: 10.1056/NEJM197403072901008. View

Nyulassy S, Ravingerova G, Zvarova E, Buc M . Letter: HL-A antigens in rheumatoid arthritis. Lancet. 1974; 1(7855):450-1. DOI: 10.1016/s0140-6736(74)92399-x. View

Sonozaki H, Seki H, Chang S, Okuyama M, Juji T . Human lymphocyte antigen, HL-A27, in Japanese patients with ankylosing spondylitis. Tissue Antigens. 1975; 5(2):131-6. DOI: 10.1111/j.1399-0039.1975.tb00541.x. View

Gibson D, Carpenter C, STILLMAN J, Schur P . Re-examination of histocompatibility antigens found in patients with juvenile rheumatoid arthritis. N Engl J Med. 1975; 293(13):636-8. DOI: 10.1056/NEJM197509252931305. View

Stastny P . Mixed lymphocyte cultures in rheumatoid arthritis. J Clin Invest. 1976; 57(5):1148-57. PMC: 436767. DOI: 10.1172/JCI108382. View

10.

Mitsui H, Juji T, Sonozaki H, Seki H, Watanabe N . Distribution of HLA-B27 in patients with juvenile rheumatoid arthritis. Ann Rheum Dis. 1977; 36(1):86-7. PMC: 1006637. DOI: 10.1136/ard.36.1.86. View

11.

McMichael A, Sasazuki T, McDevitt H, Payne R . Increased frequency of HLA-Cw3 and HLA-Dw4 in rheumatoid arthritis. Arthritis Rheum. 1977; 20(5):1037-42. DOI: 10.1002/art.1780200501. View

12.

Stastny P . Association of the B-cell alloantigen DRw4 with rheumatoid arthritis. N Engl J Med. 1978; 298(16):869-71. DOI: 10.1056/NEJM197804202981602. View

13.

Roitt I, Corbett M, Festenstein H, Jaraquemada D, Papasteriadis C, Hay F . HLA-DRW4 and prognosis in rheumatoid arthritis. Lancet. 1978; 1(8071):990. DOI: 10.1016/s0140-6736(78)90280-5. View

14.

Morris P, Batchelor J, Festenstein H . Matching for HLA in transplantation. Br Med Bull. 1978; 34(3):259-62. DOI: 10.1093/oxfordjournals.bmb.a071507. View

15.

Thomsen M, Morling N, SNORRASON E, Svejgaard A, Sorensen S . HLA--Dw4 and rheumatoid arthritis. Tissue Antigens. 1979; 13(1):56-60. DOI: 10.1111/j.1399-0039.1979.tb01137.x. View

16.

Dobloug J, Forre O, Thorsby E . HLA-DRw4 and rheumatoid arthritis. Lancet. 1979; 1(8115):548-9. DOI: 10.1016/s0140-6736(79)90963-2. View

17.

ROPES M, BENNETT G, COBB S, JACOX R, JESSAR R . 1958 Revision of diagnostic criteria for rheumatoid arthritis. Bull Rheum Dis. 1958; 9(4):175-6. View