Formalin-treated Bacteria As Selective B Cell Mitogens in the Study of Lymphocytes from Patients with Hypogammaglobulinaemia

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1980 Dec 1

PMID 6971196

Citations 2

Authors

G Banck

A Forsgren

Affiliations

Soon will be listed here.

Abstract

Staphylococcus aureus strain Cowan I, Haemophilus influenzae, and Branhamella catarrhalis that stimulate human B lymphocytes, but not T lymphocytes, were used to study the B lymphocyte function in patients with hypogammaglobulinaemia. Lymphocytes from two patients with no circulating B cells were not stimulated to increased DNA synthesis by these bacterial mitogens. The lymphocytes of six patients with hypogammaglobulinaemia and normal numbers of circulating B cells responded to the bacterial mitogens but in five patients the response was decreased in comparison with healthy controls.

Citing Articles

Formalin-treated bacteria as selective B cell mitogens: results in primary and acquired immunodeficiencies.

Sirianni M, Pucillo L, Fiorilli M, Aiuti F, Banck G, Forsgren A Clin Exp Immunol. 1981; 45(2):393-8.

PMID: 6976247 PMC: 1537368.

Isolation and characterization of an outer membrane protein of Salmonella paratyphi B: a mitogen and polyclonal activator of human B lymphocytes.

Sager S, Virella G, Chen W, Fudenberg H Immunology. 1984; 52(1):67-78.

PMID: 6370841 PMC: 1454589.

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