Ultrastructural Studies of Allergic Contact Dermatitis in Man. Infiltrating Cells at the Earliest Phase of Spongiotic Bulla Formation

Overview

Journal Arch Dermatol Res

Specialty Dermatology

Date 1980 Jan 1

PMID 6967715

Citations 3

Authors

J Komura

M Oguchi

T Aoshima

S OFUJI

Affiliations

Soon will be listed here.

Abstract

The kind and fine structure of mononuclear cells appearing in the epidermis at about 6 h of allergic contact dermatitis were examined by electron microscopy. They were monocytes and lymphocytes, the number being about equal. The ultrastructure of monocytes was that described for normal ones in blood, and apparently actively moving, streching the intercellular connections of the keratinocytes. Lymphocytes displayed a round or oval nucleus with some electron-dense cytoplasm which contained ribosomes and polysomes but only occasional mitochondria and Golgi complexes.

Citing Articles

Ultrastructural studies of allergic contact dermatitis in man. Epidermal cell changes at 3, 6, and 12 h after application of DNCB.

Komura J, OFUJI S Arch Dermatol Res. 1980; 267(3):275-82.

PMID: 7406537 DOI: 10.1007/BF00403848.

Ultrastructural studies of spontaneously regressing plane warts. Macrophages attack verruca-epidermal cells.

Oguchi M, Komura J, Tagami H, OFUJI S Arch Dermatol Res. 1981; 270(4):403-11.

PMID: 7283468 DOI: 10.1007/BF00403784.

Auto-oxidative damage in Behçet's disease--endothelial cell damage following the elevated oxygen radicals generated by stimulated neutrophils.

Niwa Y, Miyake S, Sakane T, Shingu M, Yokoyama M Clin Exp Immunol. 1982; 49(1):247-55.

PMID: 7127901 PMC: 1536650.

References

Barber T, Alter B . Ultrastructure of effector--target cell interaction in secondary cell-mediated lympholysis. Scand J Immunol. 1978; 7(1):57-66. DOI: 10.1111/j.1365-3083.1978.tb00426.x. View

Thomas D, Forni G, Shevach E, Green I . The role of the macrophage as the stimulator cell in contact sensitivity. J Immunol. 1977; 118(5):1677-81. View

Toma V, Heyns A, Retief F . The identification of human T and B lymphocytes by electron microscopy. J Immunol Methods. 1977; 17(1-2):91-100. DOI: 10.1016/0022-1759(77)90080-1. View

Stingl G, Katz S, Shevach E, Rosenthal A, Green I . Analogous functions of macrophages and Langerhans cells in the initiation in the immune response. J Invest Dermatol. 1978; 71(1):59-64. DOI: 10.1111/1523-1747.ep12544055. View

BANDMANN H . [Monocytes in experimental contact eczema. (1. Contribution to the problem of the composition of inflammatory infiltrates in allergic reactions of the skin)]. Hautarzt. 1967; 18(3):122-33. View

Dennert G, Hatlen L . Are contact hypersensitivity cells cytotoxic?. Nature. 1975; 257(5526):486-8. DOI: 10.1038/257486a0. View

Medenica M, ROSTENBERG Jr A . A comparative light and electron microscopic study of primary irritant contact dermatitis and allergic contact dermatitis. J Invest Dermatol. 1971; 56(4):259-71. DOI: 10.1111/1523-1747.ep12260992. View

Sanderson C, GLAUERT A . The mechanism of T cell mediated cytotoxicity. V. Morphological studies by electron microscopy. Proc R Soc Lond B Biol Sci. 1977; 198(1132):315-323. DOI: 10.1098/rspb.1977.0100. View

Wolff H . Foreign cell acantholysis. Electron microscopic study on the pathodynamics of exocytosis. Arch Dermatol Forsch. 1973; 247(2):145-60. View

10.

Le Bouteiller P, KINSKY R, Vujanovic N, Duc H, VOISIN G . Morphological differences between thymus- and bone marrow-derived lymphocytes. II. An electron microscopic and experimental study in unstimulated mice. Differentiation. 1976; 6(3):125-41. DOI: 10.1111/j.1432-0436.1976.tb01479.x. View

11.

Braun-Falco O, Wolff H . [Ultrastructural changes of the epidermis in allergic patch test reaction]. Arch Dermatol Forsch. 1970; 240(1):23-37. View

12.

Komura J, OFUJI S . Ultrastructural studies of allergic contact dermatitis in man. Epidermal cell changes at 3, 6, and 12 h after application of DNCB. Arch Dermatol Res. 1980; 267(3):275-82. DOI: 10.1007/BF00403848. View

13.

Kalina M, Berke G . Contact regions of cytotoxic T lymphocyte-target cell conjugates. Cell Immunol. 1976; 25(1):41-51. DOI: 10.1016/0008-8749(76)90095-2. View

14.

BANDMANN H . [Contribution on to the histopathology of allergic epicutaneous test reactions. Part 1. Allergic contact eczema and the epicutaneous patch test with previous research in the histopathology of reactions caused by the patch test]. Hautarzt. 1960; 11:258-62. View

15.

Firket H, Degiovanni G . Ultrastructural study of the relationship between immune cytotoxic lymphoid cells and target cells in vitro. Virchows Arch B Cell Pathol. 1975; 17(3):229-38. DOI: 10.1007/BF02912850. View

16.

Liepins A, Faanes R, Lifter J, Choi Y, de Harven E . Ultrastructural changes during T-lymphocyte-mediated cytolysis. Cell Immunol. 1977; 28(1):109-24. DOI: 10.1016/s0008-8749(77)80011-7. View