Preliminary Studies with Citalopram (LU 10-171), a Specific 5-HT-reuptake Inhibitor, As Antidepressant

Overview

Journal Prog Neuropsychopharmacol Biol Psychiatry

Specialty Psychiatry

Date 1982 Jan 1

PMID 6959196

Citations 8

Authors

M Gastpar

G Gastpar

Affiliations

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Abstract

1. Ten hospitalized, depressive, female patients above the age of 50 have been treated in a 3 week open trial with citalopram, a specific 5-HT-uptake inhibitor. 2. Six full and two partial responders demonstrate a recovery rate within the well known range for tricyclic antidepressant drugs. 3. Early onset of clinical effect and minimal side effects indicate that citalopram is possible a new effective antidepressant.

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Biochemical effects and drug levels in rats after long-term treatment with the specific 5-HT-uptake inhibitor, citalopram.

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Comparative animal studies on cardiovascular toxicity of tri- and tetracyclic antidepressants and citalopram; relation to drug plasma levels.

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Clinical and biochemical effects of citalopram, a selective 5-HT reuptake inhibitor--a dose-response study in depressed patients.

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Kinetics of citalopram in elderly patients.

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