Alpha 2.0
Login Register
» Articles » PMID: 6954498

NMR Chemical Shift Imaging in Three Dimensions

Overview
Journal Proc Natl Acad Sci U S A
Specialty Science
Date 1982 Jun 1
PMID 6954498
Citations 165
Authors
T R Brown
B M Kincaid
K Ugurbil
Affiliations
Soon will be listed here.
Abstract

A method for obtaining the three-dimensional distribution of chemical shifts in a spatially inhomogeneous sample using Fourier transform NMR is presented. The method uses a sequence of pulsed field gradients to measure the Fourier transform of the desired distribution on a rectangular grid in (k,t) space. Simple Fourier inversion then recovers the original distribution. An estimated signal/noise ratio of 20 in 10 min is obtained for an "image" of the distribution of a 10 mM phosphorylated metabolite in the human head at a field of 20 kG with 2-cm resolution.

Citing Articles

Metabolic checkpoints in glioblastomas: targets for new therapies and non-invasive detection.

Li W, Wang Z, Chen S, Zuo M, Xiang Y, Yuan Y Front Oncol. 2024; 14:1462424.

PMID: 39678512 PMC: 11638224. DOI: 10.3389/fonc.2024.1462424.

Metabolic imaging in living plants: A promising field for chemical exchange saturation transfer (CEST) MRI.

Mayer S, Rolletschek H, Radchuk V, Wagner S, Ortleb S, Gundel A Sci Adv. 2024; 10(38):eadq4424.

PMID: 39292788 PMC: 11409970. DOI: 10.1126/sciadv.adq4424.

A Quantitative Comparison of P Magnetic Resonance Spectroscopy RF Coil Sensitivity and SNR between 7T and 10.5T Human MRI Scanners Using a Loop-Dipole P-H Probe.

Li X, Zhu X, Chen W Sensors (Basel). 2024; 24(17).

PMID: 39275704 PMC: 11398117. DOI: 10.3390/s24175793.

Molecular imaging of tumor metabolism: Insight from pyruvate- and glucose-based deuterium MRI studies.

Montrazi E, Sasson K, Agemy L, Scherz A, Frydman L Sci Adv. 2024; 10(11):eadm8600.

PMID: 38478615 PMC: 10936946. DOI: 10.1126/sciadv.adm8600.

High-Dimensional MR Spatiospectral Imaging by Integrating Physics-Based Modeling and Data-Driven Machine Learning: Current progress and future directions.

Lam F, Peng X, Liang Z IEEE Signal Process Mag. 2023; 40(2):101-115.

PMID: 37538148 PMC: 10398845. DOI: 10.1109/msp.2022.3203867.

References
1.
Ackerman J, Grove T, Wong G, Gadian D, Radda G . Mapping of metabolites in whole animals by 31P NMR using surface coils. Nature. 1980; 283(5743):167-70. DOI: 10.1038/283167a0. View
2.
Holland G, Hawkes R, Moore W . Nuclear magnetic resonance (NMR) tomography of the brain: coronal and sagittal sections. J Comput Assist Tomogr. 1980; 4(4):429-33. DOI: 10.1097/00004728-198008000-00002. View
3.
Hawkes R, Holland G, Moore W, Worthington B . Nuclear magnetic resonance (NMR) tomography of the brain: a preliminary clinical assessment with demonstration of pathology. J Comput Assist Tomogr. 1980; 4(5):577-86. DOI: 10.1097/00004728-198010000-00001. View
4.
Edelstein W, Hutchison J, Johnson G, Redpath T . Spin warp NMR imaging and applications to human whole-body imaging. Phys Med Biol. 1980; 25(4):751-6. DOI: 10.1088/0031-9155/25/4/017. View
5.
DOYLE F, Gore J, Pennock J, Bydder G, Orr J, STEINER R . Imaging of the brain by nuclear magnetic resonance. Lancet. 1981; 2(8237):53-7. DOI: 10.1016/s0140-6736(81)90408-6. View