Allelic Exclusion of Immunoglobulin Expression is Not Caused by Somatic Segregation

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1982 Jan 1

PMID 6952212

Citations 2

Authors

M R Wabl

M Tenkhoff

Affiliations

Soon will be listed here.

Abstract

We have investigated the karyotype of immunoglobulin-producing cells in heterozygous animals. Using a karyotypic marker for one homolog of a chromosome carrying immunoglobulin genes, we established that immunoglobulin-producing cells are heterozygous with respect to this chromosome. Therefore, allelic exclusion of immunoglobulin expression cannot be caused by somatic chromosome segregation.

Citing Articles

A theory of allelic and isotypic exclusion for immunoglobulin genes.

Wabl M, Steinberg C Proc Natl Acad Sci U S A. 1982; 79(22):6976-8.

PMID: 6817330 PMC: 347257. DOI: 10.1073/pnas.79.22.6976.

Allelic inclusion in a pre-B-cell line that generates immunoglobulin heavy chain genes in vitro.

Jack H, Wabl M Proc Natl Acad Sci U S A. 1987; 84(4):1060-4.

PMID: 3103122 PMC: 304361. DOI: 10.1073/pnas.84.4.1060.

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