Studies of Retinoids in the Prevention and Treatment of Cancer

Overview

Journal J Am Acad Dermatol

Specialty Dermatology

Date 1982 Apr 1

PMID 6950958

Citations 4

Authors

F L Meyskens

Affiliations

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Abstract

Investigation of retinoids for anticancer activity in humans, either in the chemopreventive or treatment mode, has been little studied. We summarize here our ongoing investigations in four different areas: (1) secondary prevention of cervical dysplasia with topical application of all-trans-retinoic acid; (2) adjuvant treatment of resected high-risk stage I and II malignant melanoma with bacille Calmette Guérin (BCG) plus or minus oral vitamin A; (3) topical vitamin A acid therapy for cutaneous metastatic melanoma; an (4) oral isotretinoin as an anticancer agent.

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Comparative study of systemic interferon alfa-2a with oral isotretinoin and oral isotretinoin alone in the treatment of recurrent condylomata accuminata.

Cardamakis E, Kotoulas I, Dimopoulos D, Stathopoulos E, Michopoulos J, Tzingounis V Arch Gynecol Obstet. 1996; 258(1):35-41.

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Familial tylosis and carcinoma of the oesophagus.

OMahony M, Ellis J, Hellier M, Mann R, Huddy P J R Soc Med. 1984; 77(6):514-7.

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Synthetic retinoids in dermatology.

Heller E, Shiffman N Can Med Assoc J. 1985; 132(10):1129-36.

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