Inheritance and Genetic Linkage of Transcobalamin II

Overview

Journal Hum Genet

Specialty Genetics

Date 1981 Jan 1

PMID 6941922

Citations 3

Authors

S Y Yang

P Coleman

H D Ochs

B DuPont

Affiliations

Soon will be listed here.

Abstract

The genetic polymorphism of the vitamin B12 transport protein transcobalamin II (TC II) was studied in the Caucasian population and in families. There are five codominent alleles of TC II which show a Mendelian mode of inheritance. No genetic linkage of TC II was found with gene loci for ADA, GLO I, Pi, HLA, AB0 and AK1. TC II like proteins could be detected on autoradiograph of PAGE in two patients with congenital homozygosity for functional TC II deficiency. These vitamin B12 binding proteins in the patients' serum were shown not to be normal R-proteins.

Citing Articles

Distribution of genetic variants of transcobalamin II in Nigerian black populations.

Porck H, Fleming A, Frants R Am J Hum Genet. 1984; 36(3):710-7.

PMID: 6731442 PMC: 1684449.

Genetic patterns of transcobalamin II and the relationships with congenital defects.

Frater-Schroder M Mol Cell Biochem. 1983; 56(1):5-31.

PMID: 6355816 DOI: 10.1007/BF00228765.

Assignment of human transcobalamin II (TC2) to chromosome 22 using somatic cell hybrids and monosomic meningioma cells.

Arwert F, Porck H, Frater-Schroder M, Brahe C, Geurts van Kessel A, Westerveld A Hum Genet. 1986; 74(4):378-81.

PMID: 3466852 DOI: 10.1007/BF00280489.

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