Stability of Globin MRNA in Terminally Differentiating Murine Erythroleukemia Cells

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 1981 Feb 1

PMID 6937265

Citations 45

Authors

V Volloch

D Housman

Affiliations

Soon will be listed here.

Abstract

The stability of globin mRNA is terminally differentiating MEL cells has been reevaluated. Previously, it had been reported that globin mRNA has a half-life of approximately 17 hr in terminally differentiating MEL cells. We show that the previous measurements of this parameter were confounded by physical instability of differentiating MEL cells. By using culture conditions that physically stabilize end-stage cells we show that the stability of globin mRNA in terminally differentiating MEL cells is equal to the value observed for ribosomal RNA, a half-life greater than 60 hr.

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