Genetics of Ia-like Alloantigens in Chickens and Linkage with B Major Histocompatibility Complex

Overview

Journal Immunogenetics

Specialties Allergy & Immunology
Genetics

Date 1980 Jan 1

PMID 6932391

Citations 7

Authors

D L Ewert

D G Gilmour

W E Briles

M D Cooper

Affiliations

Soon will be listed here.

Abstract

Two sets of backcross matings were performed to test for linkage between genes coding for the Ia-like antigens ("Ia") and the B erythrocyte antigens (Ea-B) of the chicken. Evidence is presented which indicates that the "Ia" antigens are determined by a single codominant locus and that the Ea-B and "Ia" loci are on the same chromosome. Failure to detect a single recombinant between the Ea-B and "Ia" loci out of 208 progeny suggests close linkage of the two genes with a map distance of up to about 2 centimorgans. The "Ia" genes are thus included in the B major histocompatibility complex of the chicken.

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