During Ontogeny, Ia-bearing Accessory Cells Are Found Early in the Thymus but Late in the Spleen

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 1980 Mar 1

PMID 6929512

Citations 17

Authors

C Y Lu

D I Beller

E R UNANUE

Affiliations

Soon will be listed here.

Abstract

The ontogeny of Ia-bearing accessory cells was studied in mice. Ia-bearing adherent cells from the thymus, consisting predominantly of macrophages, were found from birth. These adherent cells were able to present antigen, as measured by their ability to induce immune T-cell proliferation. In contrast, Ia-bearing adherent cells from the spleen were not found until the second week of life, and their antigen-presentation function was not present until later. The differential ontogeny of Ia-bearing accessory cells at these sites may be important in both development of immune competence and the restriction of autoimmunity.

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