Variability of Glutathione S-transferase of Human Erythrocytes

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1980 Jan 1

PMID 6928733

Citations 5

Authors

E M Scott

R C Wright

Affiliations

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Abstract

Glutathione transferase (GST) of human erythrocytes, while homogeneous upon electrophoresis, varied more than sixfold in amount in individuals. The levels of this enzyme were found to be inherited, but no practical way was devised to use this enzyme as a genetic marker.

Citing Articles

Analysis of candidate modifier loci for the severity of colonic familial adenomatous polyposis, with evidence for the importance of the N-acetyl transferases.

Crabtree M, Fletcher C, Churchman M, Hodgson S, Neale K, Phillips R Gut. 2004; 53(2):271-6.

PMID: 14724163 PMC: 1774929. DOI: 10.1136/gut.2003.015586.

Polymorphism of glutathione S-transferase in laboratory rats.

Matsumoto K, Gasser D Biochem Genet. 1983; 21(11-12):1209-15.

PMID: 6670994 DOI: 10.1007/BF00488472.

Erythrocyte glutathione S-transferase. Electrophoretic identification of two enzyme forms.

Strange R, Hirrell P, Kitley G, Hopkinson D, Cotton W Biochem J. 1983; 215(1):213-6.

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Human genes for glutathione S-transferases.

Laisney V, Van Cong N, Gross M, FREZAL J Hum Genet. 1984; 68(3):221-7.

PMID: 6500576 DOI: 10.1007/BF00418392.

The human glutathione S-transferases: developmental aspects of the GST1, GST2, and GST3 loci.

Strange R, Davis B, Faulder C, Cotton W, Bain A, Hopkinson D Biochem Genet. 1985; 23(11-12):1011-28.

PMID: 4084207 DOI: 10.1007/BF00499944.

References

Habig W, Pabst M, Jakoby W . Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974; 249(22):7130-9. View

Marcus C, Habig W, Jakoby W . Glutathione transferase from human erythrocytes. Nonidentity with the enzymes from liver. Arch Biochem Biophys. 1978; 188(2):287-93. DOI: 10.1016/s0003-9861(78)80011-3. View