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Mutation Rates from Rare Variants of Proteins in Indian Tribes

Overview
Journal Hum Genet
Specialty Genetics
Date 1978 Aug 31
PMID 689686
Citations 6
Authors
R Chakraborty
A K ROYCHOUDHURY
Affiliations
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Abstract

Recent attempts to estimate mutation rates in man have resulted in some theoretical developments. Recently, Nei (1977) provided a new formula for estimating mutation rates from electrophoretically detected rare protein variants. His formula is applied here to estimated mutation rates from such variants among the Kadars of Kerala and five tribes of Andhra Pradesh in India. The estimates seem to differ from Nei's estimate on South American Indians by an order of magnitude, although the standard errors associated with such estimates are rather large.

Citing Articles

Frequency of private electrophoretic variants and indirect estimates of mutation rate in Papua New Guinea.

Bhatia K, Blake N, Serjeantson S, Kirk R Am J Hum Genet. 1981; 33(1):112-22.

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Expected number of rare alleles per locus in a sample and estimation of mutation rates.

Chakraborty R Am J Hum Genet. 1981; 33(3):481-4.

PMID: 7246548 PMC: 1685030.

Is there a difference among human populations in the rate with which mutation produces electrophoretic variants?.

Neel J, Rothman E Proc Natl Acad Sci U S A. 1981; 78(5):3108-12.

PMID: 6942419 PMC: 319509. DOI: 10.1073/pnas.78.5.3108.

A revised indirect estimate of mutation rates in Amerindians.

Neel J, Mohrenweiser H, Rothman E, Naidu J Am J Hum Genet. 1986; 38(5):649-66.

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Presidential address. Our load of mutations and its burden of disease.

Knudson Jr A Am J Hum Genet. 1979; 31(4):401-13.

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