Homology Among DNA-binding Proteins Suggests Use of a Conserved Super-secondary Structure

Overview

Journal Nature

Specialty Science

Date 1982 Jul 29

PMID 6896364

Citations 149

Authors

R T Sauer

R R Yocum

R F Doolittle

M Lewis

C O Pabo

Affiliations

Soon will be listed here.

Abstract

The amino acid sequences of the repressor and cro proteins of phages lambda, 434 and P22 are homologous, especially in a region in which repressor and lambda cro have a similar alpha-helix-turn-alpha-helix secondary structure. Model-building studies indicate that this structure is important in DNA binding, and we suggest it may be a common feature of many DNa-binding proteins.

Citing Articles

Biological Switches: Past and Future Milestones of Transcription Factor-Based Biosensors.

De Paepe B, De Mey M ACS Synth Biol. 2024; 14(1):72-86.

PMID: 39709556 PMC: 11745168. DOI: 10.1021/acssynbio.4c00689.

Unexpected Requirement of Small Amino Acids at Position 183 for DNA Binding in the Escherichia coli cAMP Receptor Protein.

Carranza M, Rea A, Pacheco D, Montiel C, Park J, Youn H J Microbiol. 2024; 62(10):871-882.

PMID: 39240506 DOI: 10.1007/s12275-024-00169-2.

A Career's Work, the l-Arabinose Operon: How It Functions and How We Learned It.

Schleif R EcoSal Plus. 2022; 10(1):eESP00122021.

PMID: 36519894 PMC: 10729937. DOI: 10.1128/ecosalplus.ESP-0012-2021.

Growth Substrate and Prophage Induction Collectively Influence Metabolite and Lipid Profiles in a Marine Bacterium.

Basso J, Jones K, Jacobs K, Christopher C, Fielland H, Campagna S mSystems. 2022; 7(5):e0058522.

PMID: 35972149 PMC: 9600351. DOI: 10.1128/msystems.00585-22.

How structural biology transformed studies of transcription regulation.

Wolberger C J Biol Chem. 2021; 296:100741.

PMID: 33957125 PMC: 8163980. DOI: 10.1016/j.jbc.2021.100741.