Leukotrienes C and D Induce Aspirin-sensitive Bronchoconstriction in the Guinea-pig

Overview

Journal Agents Actions

Specialty Pharmacology

Date 1981 Dec 1

PMID 6896115

Authors

B B Vargaftig

J Lefort

R C Murphy

Affiliations

Soon will be listed here.

Abstract

Branchoconstriction in the guinea-pig due to leukotrienes C4 and D4 in vivo and in vitro was suppressed by aspirin. Since contracting effects of putative mediators of bronchial asthma should be refractory to inhibition of cyclooxygenase, our results indicate that release of leukotrienes in the guinea-pig does not alone account for anaphylactic bronchoconstriction.

References

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