"Two Route Chemotherapy" Using Cis-diamminedichloro-platinum(II) and Its Antidote, Sodium Thiosulfate, for Peritoneally Disseminated Cancer in Rats

Overview

Journal Gan

Specialty Oncology

Date 1982 Jun 1

PMID 6890002

Citations 13

Authors

S Taniguchi

T Baba

Affiliations

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Abstract

The effects of "two route chemotherapy" using cis-diamminedichloroplatinum-(II) (DDP) and its antidote sodium thiosulfate (STS), given ip and sc, respectively, were assessed in the case of peritoneally disseminated cancer in rats. Administration of STS sc to mice 1 min before DDP ip was found to be the most effective in protecting the animals against the lethal toxicity of DDP. The LD50 values of DDP ip with and without STS were about 55 mg/kg and 14 mg/kg, respectively. This "two route chemotherapy" using DDP and STS was significantly superior in therapeutic efficacy to single treatment with DDP.

Citing Articles

Experimental and clinical studies on the intraperitoneal administration of cis-diamminedichloroplatinum (II) for peritoneal carcinomatosis caused by gastric cancers.

Furukawa T, Kumai K, Kubota T, Hirahata S, Shimizu H, Matsui H Surg Today. 1993; 23(4):298-306.

PMID: 8318783 DOI: 10.1007/BF00309046.

"Two route infusion chemotherapy" using cis-Diamminedichloroplatinum (II) and its antidote, sodium thiosulfate, for metastatic liver tumors in rats.

Uozumi J, Sagiyama K, Taniguchi S, Iwamoto Y, Aoki K, Baba T Jpn J Surg. 1982; 12(6):456-62.

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Sodium thiosulfate inhibits cis-diamminedichloroplatinum (II) activity.

Uozumi J, Ishizawa M, Iwamoto Y, Baba T Cancer Chemother Pharmacol. 1984; 13(2):82-5.

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Inactivation of cis-diamminedichloroplatinum (II) in blood and protection of its toxicity by sodium thiosulfate in rabbits.

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