Calcium-dependent [3H]acetylcholine Release and Muscarinic Autoreceptors in Rat Cortical Synaptosomes During Development

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 1983 May 1

PMID 6888653

Citations 1

Authors

M Marchi

A Caviglia

P Paudice

M Raiteri

Affiliations

Soon will be listed here.

Abstract

A number of presynaptic cholinergic parameters (high affinity [3H]choline uptake, [3H]acetylcholine synthesis, [3H]acetylcholine release, and autoinhibition of [3H]acetylcholine release mediated by muscarinic autoreceptors) were comparatively analyzed in rat brain cortex synaptosomes during postnatal development. These various functions showed a differential time course during development. At 10 days of age the release of [3H]acetylcholine evoked by 15 mM KCl from superfused synaptosomes was Ca2+-dependent but insensitive to the inhibitory action of extrasynaptosomal acetylcholine. The muscarinic autoreceptors regulating acetylcholine release were clearly detectable only at 14 days, indicating that their appearance may represent a criterion of synaptic maturation more valuable than the onset of a Ca2+-dependent release.

Citing Articles

The activation of phosphatidylinositol turnover is not directly involved in the modulation of neurotransmitter release mediated by presynaptic muscarinic receptors.

Marchi M, Fontana G, Paudice P, Raiteri M Neurochem Res. 1988; 13(9):903-7.

PMID: 2906409 DOI: 10.1007/BF00970760.

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