Nature of the Stimulation of Biogenesis of Cholesterol in the Liver by Noradrenaline

Overview

Journal Biochem J

Specialty Biochemistry

Date 1977 Mar 15

PMID 68775

Citations 5

Authors

R George

T Ramasarma

Affiliations

Soon will be listed here.

Abstract

1. Administration of noradrenaline increased the incorporation of [1-14C]acetate into hepatic sterols and the activity of liver microsomal 3-hydroxy-3-methylglutaryl-CoA reductase. 2. The stimulation was observed at short time-intervals with a maximum at 4h and was progressive with increasing concentrations of noradrenaline. 3. Protein synthesis de novo was a necessary factor for the effect. 4. The stimulatory effect was not mediated through the adrenergic receptors, but appears to involve a direct action of the hormone within the hepatocyte.

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