Degeneration of Cochlear Neurons After Amikacin Intoxication in the Rat

Overview

Journal Arch Otorhinolaryngol

Specialty Otorhinolaryngology

Date 1983 Apr 1

PMID 6870653

Citations 25

Authors

E BICHLER

H SPOENDLIN

H Rauchegger

Affiliations

Soon will be listed here.

Abstract

Intoxication with high doses of the aminoglycoside antibiotic amikacin in a supranormal sensitive period in the rat induces complete destruction of the inner and outer hair cells in the organ of Corti in all turns, whereas the supporting cells remain partially preserved in the upper turns. With increasing survival time, the number of ganglion cells in the spiral ganglion decreases progressively, reaching a minimum of about 10% surviving cells after 12 months. Both type I and type II neurons are subject to retrograde degeneration, although type-II cells degenerate more slowly than type-I cells. The presence or absence of supporting cells in the organ of Corti does not seem to influence neuronal degeneration. This retrograde degeneration is similar in all animals so far studied but its time course is different from different species. Retrograde degeneration after destruction of Corti's organ is a long-lasting process and is never completed at once. This must be taken into consideration in the treatment of total deafness with electric stimulation of surviving neurons.

Citing Articles

Anti-inflammatory Therapy Protects Spiral Ganglion Neurons After Aminoglycoside Antibiotic-Induced Hair Cell Loss.

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Effects of Degrees of Degeneration on the Electrical Excitation of Human Spiral Ganglion Neurons Based on a High-Resolution Computer Model.

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Spatiotemporal Developmental Upregulation of Prestin Correlates With the Severity and Location of Cyclodextrin-Induced Outer Hair Cell Loss and Hearing Loss.

Ding D, Jiang H, Manohar S, Liu X, Li L, Chen G Front Cell Dev Biol. 2021; 9:643709.

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Area-dependent change of response in the rat's inferior colliculus to intracochlear electrical stimulation following neonatal cochlear damage.

Hatano M, Kelly J, Zhang H Sci Rep. 2019; 9(1):5643.

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Endoplasmic reticulum stress is involved in spiral ganglion neuron apoptosis following chronic kanamycin-induced deafness.

Tu Y, Fan G, Sun H, Cai X, Kong W Biosci Rep. 2019; 39(2).

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