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Autoimmune Haemolytic Disease in Mice After Exposure to a Methylating Carcinogen

Overview
Journal Immunology
Specialty Allergy & Immunology
Date 1983 Jul 1
PMID 6862520
Citations 6
Authors
G Harris
P D Lawley
L J Asbery
P M Chandler
M G Jones
Affiliations
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Abstract

N-Methyl-N-nitrosourea (MNU) but not methyl methanesulphonate (MMS) induced both autoimmune haemolytic anaemia and thymic lymphoma in susceptible strains of mice, particularly the C57BL/6. These effects could be positively correlated with the formation of O6-methylguanine in target DNA. All murine lymphoid cells showed lack of ability to remove O6-methylguanine from their DNA, therefore the variation of responses between different mouse strains indicated that other host factors, probably genetic, must be involved. The results do indicate however that a potent pre-mutagenic DNA base modification can initiate the events leading to autoimmune disease in susceptible mice.

Citing Articles

Defective repair of O6-methylguanine-DNA in primary Sjögren's syndrome patients predisposed to lymphoma.

Guo K, Major G, Foster H, Bassendine M, Collier J, Ross D Ann Rheum Dis. 1995; 54(3):229-32.

PMID: 7748022 PMC: 1005562. DOI: 10.1136/ard.54.3.229.

Deficient repair of O6-methylguanine in lymphocytes from rheumatoid arthritis families may be an acquired defect.

Colaco C, Harris G, Lawley P, Lydyard P, Roitt I Clin Exp Immunol. 1988; 72(1):15-9.

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Increased sensitivity of lymphocytes from patients with systemic autoimmune diseases to DNA alkylation by the methylating carcinogen N-methyl-N-nitrosourea.

Lawley P, Topper R, DENMAN A, Hylton W, Hill I, Harris G Ann Rheum Dis. 1988; 47(6):445-51.

PMID: 3382263 PMC: 1003543. DOI: 10.1136/ard.47.6.445.

Immunotoxic potential of N-ethyl, N-nitrosourea (ENU) in CD1 mice.

Jayasekara S, Sharma R, Drown D Clin Exp Immunol. 1989; 77(2):294-8.

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Purification to homogeneity and partial amino acid sequence of a fragment which includes the methyl acceptor site of the human DNA repair protein for O6-methylguanine.

Major G, GARDNER E, Carne A, Lawley P Nucleic Acids Res. 1990; 18(6):1351-9.

PMID: 2109306 PMC: 330497. DOI: 10.1093/nar/18.6.1351.

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